Pyrenosetins A-C, New Decalinoylspirotetramic Acid Derivatives Isolated by Bioactivity-Based Molecular Networking from the Seaweed-Derived Fungus sp. FVE-001.

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ID: 83882
2020
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Abstract
Marine algae represent a prolific source of filamentous fungi for bioprospecting. In continuation of our search for new anticancer leads from fungi derived from the brown alga , an endophytic sp. FVE-001 was selected for an in-depth chemical analysis. The crude fungal extract inhibited several cancer cell lines in vitro, and the highest anticancer activity was tracked to its CHCl-soluble portion. A bioactivity-based molecular networking approach was applied to C-SPE fractions of the CHCl subextract to predict the bioactivity scores of metabolites in the fractions and to aid targeted purification of anticancer metabolites. This approach led to a rapid isolation of three new decalinoylspirotetramic acid derivatives, pyrenosetins A-C (-) and the known decalin tetramic acid phomasetin (). The structures of the compounds were elucidated by extensive NMR, HR-ESIMS, FT-IR spectroscopy, [α] and Mosher's ester method. Compounds and showed high anticancer activity against malignant melanoma cell line A-375 (IC values 2.8 and 6.3 μM, respectively), in line with the bioactivity predictions. This is the first study focusing on secondary metabolites of a marine-derived sp. and the second investigation performed on the member of the genus .
Reference Key
fan2020pyrenosetinsmarine Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Fan, Bicheng;Dewapriya, Pradeep;Li, Fengjie;Blümel, Martina;Tasdemir, Deniz;
Journal Marine drugs
Year 2020
DOI
E47
URL
Keywords
fucus vesiculosus pyrenochaetopsis sp. bioactivity-based molecular networking decalin tetramic acid marine fungus phomasetin pyrenosetin

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