Nitrogen storage regulation by PII protein: lessons learned from taxonomic outliers.
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2020
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Abstract
The paper 'Interaction of N-acetyl-l-glutamate kinase with the PII signal transducer in the non-photosynthetic alga Polytomella parva: Co-evolution towards a hetero-oligomeric enzyme' by Selim et al. highlights how the study of a true taxonomic oddity, the heterotrophic unicellular alga P. parva, has been instrumental in uncovering the large potential for adaptive variation in the signaling complex of PII with the enzyme N-acetylglutamate kinase (NAGK). This complex modifies the regulatory properties of NAGK, allowing nitrogen stockpiling as arginine. In P. parva, a stable PII-NAGK complex is formed which lacks regulation by canonical PII effectors but which exhibits novel adaptive responses to nitrogen abundance mediated by glutamine, a neo-effector of PII proteins of photosynthetic eukaryotes.
| Reference Key |
rubio2020nitrogenthe
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| Authors | Rubio, Vicente;Marco-Marín, Clara;Llácer, José Luis; |
| Journal | The FEBS Journal |
| Year | 2020 |
| DOI |
10.1111/febs.15189
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