Personal aging markers and ageotypes revealed by deep longitudinal profiling.

Clicks: 401
ID: 83642
2020
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #7 of 39 articles by views in Nature Medicine

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
The molecular changes that occur with aging are not well understood. Here, we performed longitudinal and deep multiomics profiling of 106 healthy individuals from 29 to 75 years of age and examined how different types of 'omic' measurements, including transcripts, proteins, metabolites, cytokines, microbes and clinical laboratory values, correlate with age. We identified both known and new markers that associated with age, as well as distinct molecular patterns of aging in insulin-resistant as compared to insulin-sensitive individuals. In a longitudinal setting, we identified personal aging markers whose levels changed over a short time frame of 2-3 years. Further, we defined different types of aging patterns in different individuals, termed 'ageotypes', on the basis of the types of molecular pathways that changed over time in a given individual. Ageotypes may provide a molecular assessment of personal aging, reflective of personal lifestyle and medical history, that may ultimately be useful in monitoring and intervening in the aging process.
Reference Key
ahadi2020personalnature Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ahadi, Sara;Zhou, Wenyu;Schüssler-Fiorenza Rose, Sophia Miryam;Sailani, M Reza;Contrepois, Kévin;Avina, Monika;Ashland, Melanie;Brunet, Anne;Snyder, Michael;
Journal Nature Medicine
Year 2020
DOI
10.1038/s41591-019-0719-5
URL
Keywords
self-management wellness health professional healthcare provider demanding work environment individual wellness personal wellness somatology

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.