Protective role of brain derived neurotrophic factor (BDNF) in obstructive sleep apnea syndrome (OSAS) patients.

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ID: 83625
2020
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Abstract
Obstructive sleep apnea syndrome (OSAS) is a common disorder characterized by repeated episodes of upper airways collapse during the sleep. The following intermittent hypoxia triggers a state of chronic inflammation, which also interests the nervous system leading to neuronal damage and increased risk of cognitive impairment. Brain derived neurotrophic factor (BDNF) is a growth factor often associated with neuroplasticity and neuroprotection whose levels increase in several condition associated with neuronal damage. However, whether patients affected by OSAS have altered BDNF levels and whether such alteration may be reflective of their cognitive impairment is still controversial. Here we show that, when compared to healthy control volunteers, OSAS patients have increased serum levels of BDNF. Moreover, OSAS patients with the higher levels of BDNF also have reduced neurocognitive impairment as measured by The Montreal Cognitive Assessment (MoCA) questionnaire. Treatment with standard non-invasive mechanical ventilation (CPAP) also was able to ameliorate the level of cognitive impairment. Altogether our results indicate that BDNF levels represent a neuroprotective response to intermittent hypoxia in OSAS patients.
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flores2020protectiveplos Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Flores, Krisstopher Richard;Viccaro, Fausta;Aquilini, Mauro;Scarpino, Stefania;Ronchetti, Francesco;Mancini, Rita;Di Napoli, Arianna;Scozzi, Davide;Ricci, Alberto;
Journal PloS one
Year 2020
DOI
10.1371/journal.pone.0227834
URL
Keywords
ethics education, medical undergraduates, learning theories.

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