Metabolic regulation of epigenetic remodeling in immune cells.

Clicks: 374
ID: 83109
2020
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Ranked #6 of 40 articles by views in current opinion in biotechnology

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Abstract
Immune cells are capable of sensing various signals in the microenvironment and turning on specific immune functions in response. The appropriate transition of immune cells into diverse functional states, which is crucial for immunity, involves complex and well-regulated changes in transcriptional program. Accumulating evidence shows that epigenetic remodeling plays a central role in mediating the transcriptional program for immune cell activation and immunological memory. Concurrently, immune cells undergo significant metabolic reprogramming during immune response. Here we review recent studies that demonstrate shifts in metabolic state can orchestrate immune cell functions through its impact on epigenetic remodeling, and the microenvironment can exert its influence on immune cells through the metabolic regulation of epigenetics. We also discuss the systems biology approaches that enabled these discoveries.
Reference Key
britt2020metaboliccurrent Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Britt, Emily C;John, Steven V;Locasale, Jason W;Fan, Jing;
Journal current opinion in biotechnology
Year 2020
DOI
S0958-1669(19)30146-6
URL
Keywords
Enzyme biological anaerobic digestion pretreatment high strength wastewater

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