Non-viral reprogramming and induced pluripotent stem cells for cardiovascular therapy.

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ID: 83107
2020
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Ranked #4 of 4 articles by views in differentiation; research in biological diversity

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Abstract
Despite significant effort devoted to developing new treatments and procedures, cardiac disease is still one of the leading causes of death in the world. The loss of myocytes due to ischemic injury remains a major therapeutic challenge. However, cell-based therapy to repair the injured heart has shown significant promise in basic and translation research and in clinical trials. Embryonic stem cells have been successfully used to improve cardiac outcomes. Unfortunately, treatment with these cells is complicated by ethical and legal issues. Recent progress in developing induced pluripotent stem cells (iPSCs) using non-viral vectors has made it possible to derive cardiomyocytes for therapy. This review will focus on these non-integration-based approaches for reprogramming and their therapeutic advantages for cardiovascular medicine.
Reference Key
panda2020nonviraldifferentiation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Panda, Arunima;Gurusamy, Narasimman;Rajasingh, Sheeja;Carter, Hannah-Kaye;Thomas, Edwin L;Rajasingh, Johnson;
Journal differentiation; research in biological diversity
Year 2020
DOI
S0301-4681(20)30001-3
URL
Keywords
induced pluripotent stem cells cardiomyocytes non-viral reprogramming regenerative therapy somatic cell reprogramming

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