Metabolomics in the Context of Plant Natural Products Research: From Sample Preparation to Metabolite Analysis.

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2020
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Abstract
Plant-derived natural products have long been considered a valuable source of lead compounds for drug development. Natural extracts are usually composed of hundreds to thousands of metabolites, whereby the bioactivity of natural extracts can be represented by synergism between several metabolites. However, isolating every single compound from a natural extract is not always possible due to the complex chemistry and presence of most secondary metabolites at very low levels. Metabolomics has emerged in recent years as an indispensable tool for the analysis of thousands of metabolites from crude natural extracts, leading to a paradigm shift in natural products drug research. Analytical methods such as mass spectrometry (MS) and nuclear magnetic resonance (NMR) are used to comprehensively annotate the constituents of plant natural products for screening, drug discovery as well as for quality control purposes such as those required for phytomedicine. In this review, the current advancements in plant sample preparation, sample measurements, and data analysis are presented alongside a few case studies of the successful applications of these processes in plant natural product drug discovery.
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salem2020metabolomicsmetabolites Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Salem, Mohamed A;Perez de Souza, Leonardo;Serag, Ahmed;Fernie, Alisdair R;Farag, Mohamed A;Ezzat, Shahira M;Alseekh, Saleh;
Journal Metabolites
Year 2020
DOI
E37
URL
Keywords
NMR Mass spectrometry Gas chromatography metabolomics drug discovery liquid chromatography metabolite extraction plant natural products

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