Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy.

Clicks: 283
ID: 82537
2020
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #27 of 84 articles by views in Cells

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
The RAS/RAF/MEK/ERK (MAPK) signaling cascade is essential for cell inter- and intra-cellular communication, which regulates fundamental cell functions such as growth, survival, and differentiation. The MAPK pathway also integrates signals from complex intracellular networks in performing cellular functions. Despite the initial discovery of the core elements of the MAPK pathways nearly four decades ago, additional findings continue to make a thorough understanding of the molecular mechanisms involved in the regulation of this pathway challenging. Considerable effort has been focused on the regulation of RAF, especially after the discovery of drug resistance and paradoxical activation upon inhibitor binding to the kinase. RAF activity is regulated by phosphorylation and conformation-dependent regulation, including auto-inhibition and dimerization. In this review, we summarize the recent major findings in the study of the RAS/RAF/MEK/ERK signaling cascade, particularly with respect to the impact on clinical cancer therapy.
Reference Key
degirmenci2020targetingcells Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Degirmenci, Ufuk;Wang, Mei;Hu, Jiancheng;
Journal Cells
Year 2020
DOI
E198
URL
Keywords
neoplasm braf(v600e) raf inhibitors ras gtpases, raf family kinases ras/raf/mek/erk signaling paradoxical activation protein–protein interactions synthetic lethal artificial intelligence self-testing blockchain novel coronavirus disease-19

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.