To TAP or not to TAP: alternative peptides for immunotherapy of cancer.

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2020
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Abstract
Intracellular processing of antigens is crucial for the generation of T cell immunity towards cancers, since cleaved protein products are the molecular targets of these adaptive lymphocytes. The majority of antigenic peptides requires the TAP transporter to gain access to the peptide loading complex in the ER lumen where they bind MHC class I (MHC-I). This pivotal role of TAP in antigen processing makes the system vulnerable for modifications in cancer cells and indeed human cancers frequently silence this gene epigenetically. Interestingly, TAP-independent processing pathways then become apparent and partly restore MHC class I presentation with alternative peptides. In this review we discuss recent insights on how TAP-independent processing of immunogenic peptides occurs, and how these antigens can be exploited for cancer immunotherapy.
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marijt2020tocurrent Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Marijt, Koen A;van Hall, Thorbald;
Journal current opinion in immunology
Year 2020
DOI
S0952-7915(19)30101-3
URL
Keywords
entropy critical exponents critical phenomena landau theory magnetic anisotropy magnetic phase transitions

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