Inhibition of RNA Helicases of ssRNA+ Virus Belonging to Flaviviridae, Coronaviridae and Picornaviridae Families

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2011
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Abstract
Many viral pathogens encode the motor proteins named RNA helicases which display various functions in genome replication. General strategies to design specific and selective drugs targeting helicase for the treatment of viral infections could act via one or more of the following mechanisms: inhibition of the NTPase activity, by interferences with ATP binding and therefore by limiting the energy required for the unwinding and translocation, or by allosteric mechanism and therefore by stabilizing the conformation of the enzyme in low helicase activity state; inhibition of nucleic acids binding to the helicase; inhibition of coupling of ATP hydrolysis to unwinding; inhibition of unwinding by sterically blocking helicase translocation. Recently, by in vitro screening studies, it has been reported that several benzotriazole, imidazole, imidazodiazepine, phenothiazine, quinoline, anthracycline, triphenylmethane, tropolone, pyrrole, acridone, small peptide, and Bananin derivatives are endowed with helicase inhibition of pathogen viruses belonging to Flaviviridae, Coronaviridae, and Picornaviridae families.
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Authors Briguglio, Irene;Piras, Sandra;Corona, Paola;Carta, Antonio;
Journal international journal of medicinal chemistry
Year 2011
DOI
DOI not found
URL
http://dx.doi.org/10.1155/2011/213135
Keywords
chemistry Organic Chemistry Therapeutics. Pharmacology Materials of engineering and construction. Mechanics of materials Chemical technology Science plant ecology water supply for domestic and industrial purposes energy industries. energy policy. fuel trade river, lake, and water-supply engineering (general)

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