Phenotypic characterization of macrophages in the BMB sample of human acute leukemia.

Tiklamalar: 451
ID: 81816
2020
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Macrophages within tissues display a strong plastic ability in respond to environmental cues in both physiologic influences and disease. However, the macrophage phenotype and its distribution in the bone marrow biopsies (BMB) samples of human acute leukemia (AL) remain poorly understood. In this study, 97 BMB samples of patients with acute leukemia and 30 iron-deficiency anemias (IDA) as control group were evaluated with immunohistochemistry. In comparison with controls, the counts of CD68, CD163, and CD206macrophages were remarkably increased in BMB samples of acute leukemia (P < 0.01), as well as their infiltration density was roaring up-regulation (P < 0.01). The expression levels of CD68, CD163, and CD206macrophages were decreased in patients with complete remission, but there still existed statistically significant contrast to the control group (P < 0.01). The ratios of the CD163-positive cells or CD206-positive cells to CD68-positive cells were most prevalent in the BMB samples of human acute leukemia compared with the control group (P < 0.01), which support that macrophages were polarized to M2 macrophages.
Referans Anahtari
song2020phenotypicannals Kullanarak makale yazarken otomatik alinti icin bu anahtari kullanin SciMatic Makale Yoneticisi veya Tez Yoneticisi
Yazarlar Song, Jian-Xin;Wen, Yan;Li, Rui-Wei;Dong, Ting;Tang, Yi-Fei;Zhang, Juan-Juan;Sa, Ya-Lian;
Dergi Annals of hematology
Yil 2020
DOI
10.1007/s00277-020-03912-y
URL
Anahtar Kelimeler
macrophage immunohistochemistry phenotype acute leukemia bone marrow of biopsy

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