Allicin inhibits proliferation and promotes apoptosis of human epidural scar fibroblasts.

Clicks: 316
ID: 81378
2020
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #24 of 82 articles by views in world neurosurgery

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Allicin can suppress liver and cardiac fibrosis, thus we hypothesize that it may prevent scar tissue from extensive epidural fibrosis after laminectomy.Human epidural scar fibroblasts were isolated from surgical specimen, and treated by allicin at a gradient of concentrations. The morphology, viability, migration rate, cell cycle and apoptosis rate were measured by fluorescence microscope, CCK-8 assay, scratch assay and flow cytometry. Western Blot was used to measure the expression level of proliferation-related proteins.After treated by allicin, cell viability (p=0.042*) and migration rate (p=0.010* in scratch assay, and p=0.025* in Transwell assay) decreased significantly in a dose-dependent manner. The percentage of G1 phase cells significantly decreased (p=0.017*), while that of S phase (p=0.096*) and G2 (p=0.038*) phase cells significantly increased in a dose-dependent manner. Similarly, the percentage of apoptotic cells increased significantly in a dose-dependent manner (p=0.036*). Comparing with control group, the expression level of PCNA protein (p=0.081) and Bcl-2 protein (p=0.029*) significantly decreased, while the Bax protein level significantly increased (p=0.017*).Allicin can suppress human epidural scar fibroblasts migration, induce cell apoptosis, and block cell proliferation at S phase and G2 phase.
Reference Key
sun2020allicinworld Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sun, Hui-Hui;Wang, Jing-Cheng;Feng, Xin-Min;Zhu, Shou-Lei;Cai, Jun;
Journal world neurosurgery
Year 2020
DOI
S1878-8750(20)30038-3
URL
Keywords
apoptosis proliferation fibroblasts allicin epidural fibrosis

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.