Antiretroviral Activity Of a Novel Pyrimidyl-Di(Diazaspiroalkane) Derivative.

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Abstract
A novel compound, 3,3'-(5-nitropyrimidine-4,6-diyl)bis-3,12-diaza-6,9-diazoniadispiro[5.2.5.2]hexadecane tetrachloride dihydrochloride, was synthesized. The compound was found to inhibit the replication of various viral families by blocking specific heparan sulfate receptors on the host cell's surface. In experiments, the compound was found to be highly effective against several strains of HIV retroviruses.
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novoselovaantiretroviralacta Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Novoselova, E A;Riabova, O B;Leneva, I A;Nesterenko, V G;Bolgarin, R N;Makarov, V A;
Journal acta naturae
Year Year not found
DOI
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Keywords
hiv antiviral activity heparan sulfate dispiro compounds

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