Synthesis of Tertiary Benzylic Nitriles via Nickel-Catalyzed Markovnikov Hydrocyanation of α-Substituted Styrenes.
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ID: 80651
2020
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Abstract
The Markovnikov hydrocyanation of α-substituted styrenes enables the synthesis of tertiary benzylic nitriles under nickel catalysis. The Lewis-acid-free transformation features an unprecedented functional groups tolerance, including the -OH and -NH groups. A broad range of tertiary benzylic nitriles were obtained in good to excellent yields. In addition, an asymmetric version of this reaction was preliminarily investigated.
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xing2020synthesisorganic
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| Authors | Xing, Yidan;Yu, Rongrong;Fang, Xianjie; |
| Journal | Organic letters |
| Year | 2020 |
| DOI |
10.1021/acs.orglett.9b04554
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