Vasorelaxant effects of Crataegus pentagyna: Links with arginase inhibition and phenolic profile.

Clicks: 404
ID: 80641
2020
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #63 of 1,185 articles by views in Journal of ethnopharmacology

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 1,185 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Crataegus leaves, flowers and fruits have been traditionally used to improve blood circulation, numerous preclinical and clinical studies supporting the cardiovascular benefits of Crataegus preparations. In this respect, there is very limited data on Crataegus pentagyna; in addition, the chemical profile of this species is still incompletely elucidated.The objective of this study was to examine the cardiovascular benefits of Crataegus pentagyna Waldst. et Kit. ex Willd. (small-flowered black hawthorn, Rosaceae) extracts (leaf, flower and fruit ethyl acetate extracts) and the underlying mechanisms. We hypothesized that C. pentagyna extracts might exert vasodilatory effects and inhibit arginase activity due, in large part, to their polyphenolic constituents.C. pentagyna extracts induced-relaxation and the mechanisms involved were studied ex vivo in isolated aortic rings from Sprague-Dawley rats. The inhibitory effects on bovine liver arginase I were assessed by an in vitro assay. Metabolite profiling of C. pentagyna extracts was performed and the most endothelium- and nitric oxide synthase-dependent; flower extract additionally reduced Ca entry and, to a lesser extent, Ca release from the sarcoplasmic reticulum. C. pentagyna proved to be an important source of arginase inhibitors with potential benefits in endothelial dysfunction that remains to be explored.
Reference Key
bujor2020vasorelaxantjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Bujor, Alexandra;Miron, Anca;Luca, Simon Vlad;Skalicka-Wozniak, Krystyna;Silion, Mihaela;Trifan, Adriana;Girard, Corine;Demougeot, Céline;Totoson, Perle;
Journal Journal of ethnopharmacology
Year 2020
DOI
S0378-8741(19)33794-8
URL
Keywords
caffeic acid (pubchem cid: 689043) chlorogenic acid (pubchem cid: 1794427) rutin (pubchem cid: 5280805) vasorelaxation quercetin (pubchem cid: 5280343) polyphenolic compounds aortic rings arginase inhibition citric acid (pubchem cid: 311) crataegus pentagyna waldst. et kit. ex willd. epicatechin (pubchem cid: 1203) neochlorogenic acid (pubchem cid: 5280633) nor-noha, nω-hydroxy-nor-arginine (pubchem cid: 446124)

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.