Cyclodextrin-Based Peptide Self-Assemblies (Spds) That Enhance Peptide-Based Fluorescence Imaging and Antimicrobial Efficacy.

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ID: 80566
2020
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Abstract
As a result of their high specificity for their corresponding biological targets, peptides have shown significant potential in a range of diagnostic and therapeutic applications. However, their widespread use has been limited by their minimal cell permeability and stability in biological milieus. We describe here a hepta-dicyanomethylene-4-pyran appended β-cyclodextrin () that acts as a delivery enhancing "host" for 1-bromonaphthalene-modified peptides, as demonstrated with peptide probes . Interaction between the fluorescent peptides and results in the hierarchical formation of unique supramolecular architectures, which we term supramolecular-peptide-dots (). Each (, , and ) was found to facilitate the intracellular delivery of the constituent fluorescent probes (), thus allowing spatiotemporal imaging of an apoptosis biomarker (caspase-3) and mitosis. , incorporating the antimicrobial peptide , was found to provide an enhanced therapeutic benefit against both Gram-positive and Gram-negative bacteria relative to alone. In addition, a fluorescent was prepared, which revealed greater bacterial cellular uptake compared to the peptide alone () in . (ATCC 25922) and (ATCC 25923). This latter observation supports the suggestion that the platform reported here has the ability to facilitate the delivery of a therapeutic peptide and provides an easy-to-implement strategy for enhancing the antimicrobial efficacy of known therapeutic peptides. The present findings thus serve to highlight a new and effective supramolecular delivery approach that is potentially generalizable to overcome limitations associated with functional peptides.
Reference Key
jiao2020cyclodextrinbasedjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jiao, Jin-Biao;Wang, Guan-Zhen;Hu, Xi-Le;Zang, Yi;Maisonneuve, Stéphane;Sedgwick, Adam C;Sessler, Jonathan L;Xie, Juan;Li, Jia;He, Xiao-Peng;Tian, He;
Journal Journal of the American Chemical Society
Year 2020
DOI
10.1021/jacs.9b11207
URL
Keywords
Antimicrobial activity secondary metabolites aspergillus sydowii seawater-derived fungus

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