Bridging human chaperonopathies and microbial chaperonins.

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ID: 80523
2019
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Abstract
Chaperonins are molecular chaperones that play critical physiological roles, but they can be pathogenic. Malfunctional chaperonins cause chaperonopathies of great interest within various medical specialties. Although the clinical-genetic aspects of many chaperonopathies are known, the molecular mechanisms causing chaperonin failure and tissue lesions are poorly understood. Progress is necessary to improve treatment, and experimental models that mimic the human situation provide a promising solution. We present two models: one prokaryotic (the archaeon Pyrococcus furiosus) with eukaryotic-like chaperonins and one eukaryotic (Chaetomium thermophilum), both convenient for isolation-study of chaperonins, and report illustrative results pertaining to a pathogenic mutation of CCT5.
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conway-de-macario2019bridgingcommunications Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Conway de Macario, Everly;Yohda, Masafumi;Macario, Alberto J L;Robb, Frank T;
Journal Communications biology
Year 2019
DOI
10.1038/s42003-019-0318-5
URL
Keywords
ros mapk plant immunity calcium influx bak1 cerk1 cell surface receptors fungal cell wall glycan ligand

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