Incorporation of chitosan microspheres into collagen-chitosan scaffolds for the controlled release of nerve growth factor.

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ID: 80461
2014
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Abstract
Artifical nerve scaffold can be used as a promising alternative to autologous nerve grafts to enhance the repair of peripheral nerve defects. However, current nerve scaffolds lack efficient microstructure and neurotrophic support.Microsphere-Scaffold composite was developed by incorporating chitosan microspheres loaded with nerve growth factor (NGF-CMSs) into collagen-chitosan scaffolds (CCH) with longitudinally oriented microchannels (NGF-CMSs/CCH). The morphological characterizations, in vitro release kinetics study, neurite outgrowth assay, and bioactivity assay were evaluated. After that, a 15-mm-long sciatic nerve gap in rats was bridged by the NGF-CMSs/CCH, CCH physically absorbed NGF (NGF/CCH), CCH or nerve autograft. 16 weeks after implantation, electrophysiology, fluoro-gold retrograde tracing, and nerve morphometry were performed.The NGF-CMSs were evenly distributed throughout the longitudinally oriented microchannels of the scaffold. The NGF-CMSs/CCH was capable of sustained release of bioactive NGF within 28 days as compared with others in vitro. In vivo animal study demonstrated that the outcomes of NGF-CMSs/CCH were better than those of NGF/CCH or CCH.Our findings suggest that incorporation of NGF-CMSs into the CCH may be a promising tool in the repair of peripheral nerve defects.
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zeng2014incorporationplos Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zeng, Wen;Rong, Mengyao;Hu, Xueyu;Xiao, Wei;Qi, Fengyu;Huang, Jinghui;Luo, Zhuojing;
Journal PloS one
Year 2014
DOI
DOI not found
URL
http://europepmc.org/articles/PMC4077743?pdf=render
Keywords
Veterinary medicine Medicine (General) Medicine Technology (General) Engineering (General). Civil engineering (General) Information technology Science Agriculture (General) neurosciences. biological psychiatry. neuropsychiatry sports

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