Pathobionts Associated with Inflammatory Bowel Disease.

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ID: 79853
2019
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Abstract
Gut bacteria play a key role in initiating and maintaining the inflammatory process in the gut tissues of inflammatory bowel disease (IBD) patients, by supplying antigens or other stimulatory factors that trigger immune cell activation. Changes in the composition of the intestinal microbiota in IBD patients compared to that in healthy controls and a reduced diversity of intestinal microbial species are linked to the pathogenesis of IBD. Adherent invasive (AIEC) has been linked to Crohn's disease (CD) patients, while diffusely adherent (DAEC) has been associated with ulcerative colitis (UC). Bacteriological analysis of intestinal biopsy specimens and fecal samples from IBD patients shows an increased number of strains belonging to the B2 phylogenetic group, which are typically known as extraintestinal pathogenic (ExPEC). Results from studies of both cell cultures and animal models reveal pathogenic features of these pathobionts, which may link them to IBD pathogenesis. This suggests that IBD-associated strains play a facilitative role during IBD flares. In this review, we explain IBD-associated and its role in IBD pathogenesis.
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mirsepasilauridsen2019clinical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Mirsepasi-Lauridsen, Hengameh Chloé;Vallance, Bruce Andrew;Krogfelt, Karen Angeliki;Petersen, Andreas Munk;
Journal clinical microbiology reviews
Year 2019
DOI
e00060-18
URL
Keywords
diet interleukins crohn’s disease ulcerative colitis inflammatory bowel disease probiotics tight junction escherichia coli carcinoembryonic antigen-related cell adhesion molecules 6 tumor necrosis factor receptors

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