Adherent-invasive Escherichia coli (AIEC): Cause or consequence of inflammation, dysbiosis, and rupture of cellular joints in patients with IBD?

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ID: 79834
2020
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Abstract
There are many factors contributing to the development of gastrointestinal diseases, grouped into genetic, environmental, and lifestyle factors. In recent years attention has fallen on pathogens; in particular, Bacteroides fragilis, Fusobacterium nucleatum, Escherichia coli (E. coli) and Helicobacter pylori have been studied. Several points remain to be clarified, and above all, as regards the adherent-invasive E. coli strains of E. coli, one wonders if they are a cause or a consequence of the disease. In this review, we have tried to clarify some points by examining a series of recent publications regarding the involvement of the bacterium in the pathology, even if other studies are necessary.
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Authors Perna, Angelica;Hay, Eleonora;Contieri, Marcella;De Luca, Antonio;Guerra, Germano;Lucariello, Angela;
Journal journal of cellular physiology
Year 2020
DOI
10.1002/jcp.29430
URL
Keywords
virulence factors bacterial adhesion adherent-invasive e. coli (aiec) gastrointestinal disease intestinal inflammation intramacrophage survival and replication

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