Partial and Transient Clinical Response to Omalizumab in IL-21-Induced Low STAT3-Phosphorylation on Hyper-IgE Syndrome

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ID: 7973
2019
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Abstract
Hyper-IgE syndrome (HIES) is a rare primary immunodeficiency characterized by elevated levels of immunoglobulin E (IgE), eczematous dermatitis, cold abscesses, and recurrent infections of the lung and skin caused by Staphylococcus aureus. The dominant form is characterized by nonimmunologic features including skeletal, connective tissue, and pulmonary abnormalities in addition to recurrent infections and eczema. Omalizumab is a humanized recombinant monoclonal antibody against IgE. Several studies reported clinical improvement with omalizumab in patients with severe atopic eczema with high serum IgE level. We present the case of a 37-year-old male with HIES and cutaneous manifestations, treated with humanized recombinant monoclonal antibodies efalizumab and omalizumab. After therapy for 4 years, we observed diminished eczema and serum IgE levels.
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Authors Alonso-Bello, Cesar Daniel;Jiménez-Martínez, María del Carmen;Vargas-Camaño, María Eugenia;Hierro-Orozco, Sagrario;Ynga-Durand, Mario Alberto;Berrón-Ruiz, Laura;Alcántara-Montiel, Julio César;Santos-Argumedo, Leopoldo;Herrera-Sánchez, Diana Andrea;Lozano-Patiño, Fernando;Castrejón-Vázquez, María Isabel;Alonso-Bello, Cesar Daniel;Jiménez-Martínez, María del Carmen;Vargas-Camaño, María Eugenia;Hierro-Orozco, Sagrario;Ynga-Durand, Mario Alberto;Berrón-Ruiz, Laura;Alcántara-Montiel, Julio César;Santos-Argumedo, Leopoldo;Herrera-Sánchez, Diana Andrea;Lozano-Patiño, Fernando;Castrejón-Vázquez, María Isabel;
Journal case reports in immunology
Year 2019
DOI
10.1155/2019/6357256
URL
https://www.hindawi.com/journals/crii/2019/6357256/abs/
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