Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress

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ID: 79427
2015
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Abstract
Glucocorticoids released from the adrenal gland in response to stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis induce activity in the cellular reduction-oxidation (redox) system. The redox system is a ubiquitous chemical mechanism allowing the transfer of electrons between donor/acceptors and target molecules during oxidative phosphorylation while simultaneously maintaining the overall cellular environment in a reduced state. The objective of this review is to present an overview of the current literature discussing the link between HPA axis-derived glucocorticoids and increased oxidative stress, particularly focussing on the redox changes observed in the hippocampus following glucocorticoid exposure.
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Authors Spiers, Jereme G.;eChen, Hsiao-Jou Cortina;eSernia, Conrad;Lavidis, Nickolas A.;
Journal Frontiers in neuroscience
Year 2015
DOI
DOI not found
URL
http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00456/full
Keywords
neurosciences. biological psychiatry. neuropsychiatry stress oxidative stress reactive oxygen species corticosterone hypothalamic-pituitary-adrenal axis neuropsychiatry biological psychiatry

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