(+)-Catechin, an Ingredient of Green Tea, Protects Murine Microglia From Oxidative Stress-Induced DNA Damage and Cell Cycle Arrest

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ID: 79306
2005
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Abstract
Extracts of Chinese herbs have been demonstrated to inhibit oxidative stress in vitro. In this study, we investigated the mechanism of (+)-catechin, isolated from green tea, which preserved murine microglia N9 cells from an oxidative agent tert-butylhydroperoxide (tBHP)-induced cell death. (+)-Catechin augmented the cell survival ratio after exposure to tBHP. Protective action of this drug was more efficacious than that of N-acetylcysteine, which is a putative antioxidant. DNA damage, detected by the Comet assay, was diminished with treatment of the drug. Results of flow cytometric analysis showed that the amount of intracellular • OH was decreased, and the cell cycle arrest was reversed by down-regulation of p53 phosphorylation after treatment with (+)-catechin. The reduced p53 activity followed the impairment of NF-κB translocation to the nuclear region. Then the phosphorylation of extracellular signal regulated protein kinase, a cell survival facilitative signal, was upregulated at the later stage. Taken together, (+)-catechin inhibited tBHP-induced translocation of NF-κB to improve cellular survival. Keywords:: (+)-catechin, DNA damage, cell cycle arrest, NF-κB, p53
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Authors Qing Huang, Li-Jun Wu, Shin-ichi Tashiro, Hui-Yuan Gao, Satoshi Onodera, Takashi Ikejima
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Journal Journal of pharmacological sciences
Year 2005
DOI
DOI not found
URL
http://www.sciencedirect.com/science/article/pii/S1347861319322108
Keywords
Organic Chemistry Pharmacy and materia medica Therapeutics. Pharmacology Medicine

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