Collacyclumines A-D from the endophytic fungus Colletotrichum salsolae SCSIO 41021 isolated from the mangrove Kandelia candel.

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2019
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Abstract
Four undescribed alkaloids, namely collacyclumines A-D, along with a known analogue, agrocybenine, were isolated from the endophytic fungus Colletotrichum salsolae SCSIO 41021 derived from the mangrove plant Kandelia candel (L.) Druce. Collacyclumine A represents the first case of dimeric pyrrolidine alkaloid in nature. The structures of these compounds were elucidated by a combination of NMR spectra, HRESIMS data, and X-ray diffraction experiment. A proposed biosynthetic pathway of these isolated compounds were also discussed. None of compounds showed cytotoxic effects against ten cell lines.
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Authors Lin, Xiuping;Ai, Wen;Li, Meng;Zhou, Xuefeng;Liao, Shengrong;Wang, Junfeng;Liu, Juan;Yang, Bin;Liu, Yonghong;
Journal Phytochemistry
Year 2019
DOI
S0031-9422(18)30848-3
URL
Keywords
mangrove plant collacyclumine colletotrichum salsolae endophytic fungus

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