Absolute Configuration of Mycosporine-Like Amino Acids, Their Wound Healing Properties and In Vitro Anti-Aging Effects.

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ID: 79272
2019
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Abstract
Mycosporine-like amino acids (MAAs) are water-soluble metabolites, reported to exhibit strong UV-absorbing properties. They have been found in a wide range of marine organisms, especially those that are exposed to extreme levels of sunlight, to protect them against solar radiation. In the present study, the absolute configuration of 14 mycosporine-like-amino acids was determined by combining the results of electronic circular dichroism (ECD) experiments and that of advanced Marfey's method using LC-MS. The crystal structure of a shinorine hydrate was determined from single crystal X-ray diffraction data and its absolute configuration was established from anomalous-dispersion effects. Furthermore, the anti-aging and wound-healing properties of these metabolites were evaluated in three different assays namely the inhibition of collagenase, inhibition of advanced glycation end products (AGEs) and wound healing assay (scratch assay).
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Authors Orfanoudaki, Maria;Hartmann, Anja;Alilou, Mostafa;Gelbrich, Thomas;Planchenault, Patricia;Derbré, Séverine;Schinkovitz, Andreas;Richomme, Pascal;Hensel, Andreas;Ganzera, Markus;
Journal Marine drugs
Year 2019
DOI
E35
URL
Keywords
X-ray crystallography wound healing anti-aging stereochemistry ecd mycosporine-like amino acids

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