Rh(III)-Catalyzed Coupling of Acrylic Acids and Ynenones via Olefinic C-H Activation and Michael Addition.

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ID: 79141
2019
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Abstract
Rh(III)-catalyzed coupling between acrylic acids and yndienones has been realized for the synthesis of -hydrobenzofuranone. The reaction proceeded in excellent regio- and stereoselectivity under mild and redox-neutral conditions via a sequence of carboxylic acid-directed olefinic C-H activation, alkyne insertion, and Michael addition. Representative products were found to exhibit cytotoxicity toward the A549 cancer cell line at micromolar levels.
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jiang2019rhiiicatalyzedorganic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jiang, Yuqin;Li, Pengfei;Wang, Juanjuan;Zhao, Jie;Li, Yang;Zhang, Yawen;Chang, Junbiao;Liu, Bingxian;Li, Xingwei;
Journal Organic letters
Year 2019
DOI
10.1021/acs.orglett.9b04191
URL
Keywords
layered double hydroxide flame retardancy cellulose aerogel smoke suppression

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