Enantioselective Synthesis of Fused Polycyclic Tropanes via Dearomative [3 + 2] Cycloaddition Reactions of 2-Nitrobenzofurans.

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2020
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Abstract
A straight synthetic approach to fused polycyclic tropane scaffold formation through an asymmetric dearomatization cycloaddition process of 2-nitrobenzofurans with cyclic azomethine ylides was successfully developed. In the presence of a chiral copper complex, derived from Cu(OAc) and a diphosphine ligand, a series of fused polycyclic tropane derivatives were obtained in high yields (75-91%) with excellent enantioselectivities (90-98%). The utility of this method was showcased by the facile transformation of product.
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wang2020enantioselectiveorganic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wang, Zhen;Wang, Dong-Chao;Xie, Ming-Sheng;Qu, Gui-Rong;Guo, Hai-Ming;
Journal Organic letters
Year 2020
DOI
10.1021/acs.orglett.9b04108
URL
Keywords
green manufacturing manufacturing process chinese patent medicine new technology pharmaceutical equipment

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