Impairment in Theory of Mind in Parkinson's Disease Is Explained by Deficits in Inhibition.

El deterioro de la teoría de la mente en la enfermedad de Parkinson se explica por déficits en la inhibición.

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ID: 79025
2019
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Abstract
Several studies have reported that people with Parkinson's disease (PD) perform poorly on tests of 'Theory of Mind' (ToM), suggesting impairment in the ability to understand and infer other people's thoughts and feelings. However, few studies have sought to separate the processes involved in social reasoning from those involved in managing the inhibitory demands on these tests. In this study, we investigated the contribution of inhibition to ToM performance in PD.18 PD patients and 22 age-matched healthy controls performed a ToM test that separates the ability to infer someone else's perspective from the ability to inhibit one's own. Participants also completed a battery of standard measures of social and executive functioning, including measures of inhibition.The PD patients performed worse on the ToM test only when the inhibitory demands were high. When the level of inhibition required was reduced, there were no significant group differences. Furthermore, executive impairments in PD patients were limited to measures of inhibition, with disadvantages associated with poorer ToM performance in this group.This study provides convincing evidence that the apparent impairment observed on ToM tests in PD is explained by deficits in inhibition.
Diversos estudios han señalado que las personas con la enfermedad de Parkinson (EP) presentan un bajo rendimiento en pruebas de «Teoría de la Mente» (TdM), lo que sugiere una alteración en la capacidad para comprender e inferir los pensamientos y sentimientos de los demás. Sin embargo, pocos estudios han intentado separar los procesos implicados en el razonamiento social de aquellos involucrados en la gestión de las demandas inhibitorias en dichas pruebas. En este estudio, investigamos la contribución de la inhibición al rendimiento en la TdM en la EP. 18 pacientes con EP y 22 controles sanos emparejados por edad realizaron una prueba de TdM que separa la capacidad de inferir la perspectiva de otra persona de la capacidad de inhibir la propia. Los participantes también completaron una batería de medidas estándar de funcionamiento social y ejecutivo, incluidas medidas de inhibición. Los pacientes con EP mostraron un peor desempeño en la prueba de TdM únicamente cuando las demandas inhibitorias eran elevadas. Cuando se redujo el nivel de inhibición requerido, no se observaron diferencias significativas entre los grupos. Asimismo, el deterioro ejecutivo en los pacientes con EP se limitó a las medidas de inhibición, asociándose estas desventajas con un menor rendimiento en la TdM en este grupo. Este estudio proporciona pruebas convincentes de que el aparente deterioro observado en las pruebas de TdM en la EP se explica por déficits en la inhibición.
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foley2019impairmentparkinsons Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Foley, Jennifer A;Lancaster, Claire;Poznyak, Elena;Borejko, Olga;Niven, Elaine;Foltynie, Thomas;Abrahams, Sharon;Cipolotti, Lisa;
Journal parkinson's disease
Year 2019
DOI
10.1155/2019/5480913
URL
Keywords
parkinson's disease apolipoprotein e gba genomewide association study

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