New awakenings: current understanding of sleep dysfunction and its treatment in Parkinson's disease.

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ID: 79018
2019
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Abstract
The non-motor features of Parkinson's disease (PD) are increasingly being recognised. This review deals with the spectrum of sleep disorders associated with PD, which have a multifactorial aetiology and can significantly have an impact on the quality of life of patients and their carers. Some sleep disorders represent a prodromal phase of PD, with REM sleep behaviour disorder (RBD) being of particular interest in this regard, whereas others become more common as the disease advances. Understanding the pathophysiology of these sleep disturbances will hopefully lead to new treatment opportunities in the future. The recent discovery of the glymphatic system for removal of waste products from the brain has also raised the possibility that sleep disruption may cause or accelerate the underlying disease process.
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keir2019newjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Keir, Lindsay H M;Breen, David P;
Journal journal of neurology
Year 2019
DOI
10.1007/s00415-019-09651-z
URL
Keywords
sleep treatment circadian glymphatic parkinson’s

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