Parallel odor processing by mitral and middle tufted cells in the olfactory bulb.

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ID: 78446
2018
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Abstract
The olfactory bulb (OB) transforms sensory input into spatially and temporally organized patterns of activity in principal mitral (MC) and middle tufted (mTC) cells. Thus far, the mechanisms underlying odor representations in the OB have been mainly investigated in MCs. However, experimental findings suggest that MC and mTC may encode parallel and complementary odor representations. We have analyzed the functional roles of these pathways by using a morphologically and physiologically realistic three-dimensional model to explore the MC and mTC microcircuits in the glomerular layer and deeper plexiform layer. The model makes several predictions. MCs and mTCs are controlled by similar computations in the glomerular layer but are differentially modulated in deeper layers. The intrinsic properties of mTCs promote their synchronization through a common granule cell input. Finally, the MC and mTC pathways can be coordinated through the deep short-axon cells in providing input to the olfactory cortex. The results suggest how these mechanisms can dynamically select the functional network connectivity to create the overall output of the OB and promote the dynamic synchronization of glomerular units for any given odor stimulus.
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cavarretta2018parallelscientific Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Cavarretta, Francesco;Burton, Shawn D;Igarashi, Kei M;Shepherd, Gordon M;Hines, Michael L;Migliore, Michele;
Journal Scientific reports
Year 2018
DOI
10.1038/s41598-018-25740-x
URL
Keywords
movement disorders neurorehabilitation proprioceptive learning robotic rehabilitation sensorimotor learning somatosensory learning

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