Transcriptomic responses of Bisphenol S predict involvement of immune function in the cardiotoxicity of early life stage zebrafish (Danio rerio).

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ID: 78194
2019
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Abstract
Bisphenol S (BPS), an alternative for bisphenol A (BPA) that is present in thermal paper and numerous consumer products, has been linked to estrogenic, cytotoxic, genotoxic, neurotoxic and immunotoxic responses. However, the mechanisms of BPS toxicity remain poorly understood. Here, following exposure to environmentally relevant concentrations ranging from 0.1 to 100 μg/L BPS, transcriptional changes evaluated by enriched gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and Ingenuity Pathway Analysis (IPA) predicted cardiac disease and impairment of immune function in zebrafish at the embryo-to-larvae stage. Consistent with impacts predicted by transcriptional changes, significant sublethal impacts were observed ranging from reduced heart rate [8.7 ± 2.4 % reductions at 100 μg/L BPS treatment; P < 0.05] to abnormal cardiac morphology [atrial:ventricle area significantly increased; 36.2 ± 9.6% at 100 μg/L BPS treatment; P < 0.05]. RNA Sequencing analysis results also indicated changes in nitric oxide synthetase (NOS2) and interleukin 12 (IL12) after BPS treatment, which was confirmed at the protein level. Increased expression of other cytokine genes was observed in larvae, suggesting inflammatory responses may be contributing to cardiac impairment by BPS. BPS caused cardiotoxicity which temporally corresponded with inflammatory responses as predicted from RNA sequencing and confirmed at the protein and cellular levels of biological organization. Additional study is needed to find causal linkages between these responses.
Reference Key
qiu2019transcriptomicenvironmental Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Qiu, Wenhui;Chen, Bei;Greer, Justin;Magnuson, Jason;Xiong, Ying;Zhong, Hanbing;Andrzejczyk, Nicolette E;Zheng, Chunmiao;Schlenk, Daniel;
Journal Environmental science & technology
Year 2019
DOI
10.1021/acs.est.9b06213
URL
Keywords
emerging contaminants exposomics fluidics membrane effects smart system

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