Diversity-oriented synthesis of spirothiazolidinediones and their biological evaluation.

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ID: 78126
2019
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Ranked #25 of 50 articles by views in Beilstein journal of organic chemistry

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Abstract
We report a new synthetic approach to assemble spirothiazolidinediones via a [2 + 2 + 2] cyclotrimerization reaction and the derivatives were further functionalized through DA chemistry and click reaction. Using flow cytometry, it was shown for the first time that the new benzyl alcohol derivatives of thiazolidine-2,4-dione generated here are efficient apoptosis inducers in the HeLa, Hek293, U937, Jurkat, and K562 cell lines.
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kotha2019diversityorientedbeilstein Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kotha, Sambasivarao;Sreevani, Gaddamedi;Dzhemileva, Lilya U;Yunusbaeva, Milyausha M;Dzhemilev, Usein M;D'yakonov, Vladimir A;
Journal Beilstein journal of organic chemistry
Year 2019
DOI
10.3762/bjoc.15.269
URL
Keywords
apoptosis flow cytometry [2 + 2 + 2] cycloaddition biologically active spiro thiazolidinedione

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