Hepatic Lipoprotein Export and Remission of Human Type 2 Diabetes after Weight Loss.

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ID: 78075
2019
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Abstract
The role of hepatic lipoprotein metabolism in diet-induced remission of type 2 diabetes is currently unclear. Here, we determined the contributions of hepatic VLDL1-triglyceride production rate and VLDL1-palmitic acid content to changes in intra-pancreatic fat and return of first phase insulin response in a subgroup of the Diabetes Remission Clinical Trial. Liver fat, VLDL1-triglyceride production, and intra-pancreatic fat decreased after weight loss and remained normalized after 24 months of remission. First-phase insulin response remained increased only in those maintaining diabetes remission. Compared with those in remission at 24 months, individuals who relapsed after initial remission had a greater rise in the content of VLDL1-triglyceride and VLDL1-palmitic acid, re-accumulated intra-pancreatic fat, and lost first-phase response by 24 months. Thus, we observed temporal relationships between VLDL1-triglyceride production, hepatic palmitic acid flux, intra-pancreatic fat, and β-cell function. Weight-related disordered fat metabolism appears to drive development and reversal of type 2 diabetes.
Reference Key
almrabeh2019hepaticcell Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Al-Mrabeh, Ahmad;Zhyzhneuskaya, Sviatlana V;Peters, Carl;Barnes, Alison C;Melhem, Shaden;Jesuthasan, Aaron;Aribisala, Benjamin;Hollingsworth, Kieren G;Lietz, Georg;Mathers, John C;Sattar, Naveed;Lean, Michael E J;Taylor, Roy;
Journal cell metabolism
Year 2019
DOI
S1550-4131(19)30662-X
URL
Keywords
type 2 diabetes pathophysiology human palmitic acid vldl1-triglycerides diabetes remission intra-pancreatic fat liver fat twin cycle hypothesis β-cell function

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