5,4'-Dihydroxy-7,8-dimethoxyflavanone and Aliarin from Dodonaea viscosa Are Activators of PPARγ.

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ID: 77622
2018
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Abstract
PPAR agonists are widely used medications in diabetes mellitus therapy. Their role in improving adipose tissue function contributes to antidiabetic effects. The extracts of have been reported to exert antidiabetic activity. However, the effective mediators and the underlying mechanisms were largely unknown. In this study, we investigated the action on PPAR transactivation and adipocyte modulation of two typical flavonoid constituents from , 5,4'-dihydroxy-7,8-dimethoxyflavanone and aliarin. Our results showed that 5,4'-dihydroxy-7,8-dimethoxyflavanone and aliarin were potential partial PPAR agonists. The compounds induced adipogenesis in 3T3-L1 cells, with an upregulated adiponectin mRNA level and enhanced insulin sensitivity. The favorable effects of 5,4'-dihydroxy-7,8-dimethoxyflavanone, aliarin, and other flavonoid constituents on adipocytes might contribute to the antidiabetic efficacy of .
Reference Key
zhu201854dihydroxy78dimethoxyflavanoneplanta Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zhu, Jing-Jie;Ji, Jun;Hou, Ai-Jun;Wang, He-Yao;
Journal planta medica
Year 2018
DOI
10.1055/s-0043-120270
URL
Keywords
dodonaea viscosa natural products extraction pressurised hot water extraction ent-labdane diterpenoids

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