Synchronous Onset of Breast and Pancreatic Cancers: Results of Germline and Somatic Genetic Analysis

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ID: 77377
2016
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Abstract
Background: Synchronous cancers have occasionally been detected at initial diagnosis among patients with breast and ovarian cancer. However, simultaneous coexistence and diagnosis of breast and pancreas cancer has not previously been reported. Case Report: Paternal transmission of a germline BRCA2 mutation to a patient who was diagnosed at age 40 with locally advanced breast and pancreas cancer is presented. Somatic genomic analysis of both cancers with next-generation DNA sequencing confirmed the germline result and reported a variety of variants of unknown significance alterations, of which two were present in both the breast and pancreas cancers. Discussion: The possibility that genomic alterations could have been responsible for modulating the phenotypic or clinical expression of this rare presentation is considered. The authors call attention to the practice of privatizing the clinicogenetic information gained from genetic testing and call for health policy that will facilitate sharing in order to advance the outcomes of patients diagnosed with hereditary cancers.
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Authors Castro, Michael;Vierkoetter, Koah;Prager, Douglas;Montgomery, Shasta;Sedgwick, Kristin;
Journal case reports in oncology
Year 2016
DOI
DOI not found
URL
http://www.karger.com/Article/FullText/447348
Keywords
Engineering (General). Civil engineering (General) Information technology Technology Computer applications to medicine. Medical informatics Science (General) neoplasms. tumors. oncology. including cancer and carcinogens applied optics. photonics genetics electronic computers. computer science colonies and colonization. emigration and immigration. international migration

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