Synthesis, Characterization and ِAntimicrobial Activities of Some New Heterocyclic Schiff Bases Derived from Thiocarbohydrazide

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ID: 77218
2016
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Abstract
The reaction of prazolobenzothienopyrimidine-3-carbaldehyde 1 with thiocarbohydrazide afforded the Schiff’s base 3. The latter compound reacted with some electrophilic reagents to give 1,2,4-triazoles 4–6 and 1,2,4-triazines 7–9. Treatment of compound 3 with 2-cyano-3,3-bis(methylthio)acrylonitrile gave the corresponding 5-amino-4-cyano-3-methylthiopyrazole derivative 11. The reaction of pyrazole 11 with carbon disulfide afforded dithioxopyrazolopyrimidine 12. Acylation of compound 11 by using acetic anhydride yielded acetamide 13. On the other hand, the cyclocondensation of pyrazole 11 with acetic anhydride in pyridine yielded pyrazolopyrimidine derivative 14. The reactivity of compound 11 towards formamide and phenylisothiocyanate to give the pyrazolopyrimidines 15 and 16 was studied. The newly synthesized compounds were screened for their antimicrobial activity.
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elmahdy2016synthesisacta Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors El-mahdy, Kamelia;El-Kazak, Azza;Abdel-Megid, Mohamed;Seada, Magdy;Farouk, Osama;
Journal acta chimica slovenica
Year 2016
DOI
DOI not found
URL
https://journals.matheo.si/index.php/ACSi/article/view/1555
Keywords
chemistry Organic Chemistry Pharmacy and materia medica Therapeutics. Pharmacology Medicine Science

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