Current Applications of Biopolymer-based Scaffolds and Nanofibers as Drug Delivery Systems.

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ID: 76876
2019
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Abstract
The high surface-to-volume ratio of polymeric nanofibers makes them an effective vehicle for the release of bioactive molecules and compounds such as growth factors, drugs, herbal extracts and gene sequences. Synthetic polymers are commonly used as sensors, reinforcements and energy storage, whereas natural polymers are more prone to mimicking an extracellular matrix. Natural polymers are a renewable resource and classified as an environmentally friendly material, which might be used in different techniques to produce nanofibers for biomedical applications such as tissue engineering, implantable medical devices, antimicrobial barriers and wound dressings, among others. This review sheds some light on the advantages of natural over synthetic polymeric materials for nanofiber production. Also, the most important techniques employed to produce natural nanofibers are presented. Moreover, some pieces of evidence regarding toxicology and cell-interactions using natural nanofibers are discussed. Clearly, the potential extrapolation of such laboratory results into human health application should be addressed cautiously.
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de-lima-nascimento2019currentcurrent Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors de Lima Nascimento, Tatiana Rita;de Amoêdo Campos Velo, Marilia Mattar;Silva, Camila Félix;Costa Cruz, Sara Brito Silva;Gondim, Brenna Louise Cavalcanti;Mondelli, Rafael Francisco Lia;Castellano, Lúcio Roberto Cançado;
Journal current pharmaceutical design
Year 2019
DOI
10.2174/1381612825666191108162948
URL
Keywords
biopolymers nanofibers drug delivery systems biomedical research synthetic polymers toxicology.

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