The Hexameric Resorcinarene Capsule as a Brønsted Acid Catalyst for the Synthesis of Bis(heteroaryl)methanes in a Nanoconfined Space.

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ID: 76704
2019
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Abstract
Herein, we show that the hexameric resorcinarene capsule is able to catalyze the formation of bis(heteroaryl)methanes by reaction between pyrroles or indoles and carbonyl compounds (α-ketoesters or aldehydes) in excellent yields and selectivity. Our results suggest that the capsule can play a double catalytic role as a H-bond catalyst, for the initial activation of the carbonyl substrate, and as a Brønsted acid catalyst, for the dehydration of the intermediate alcohol.
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Authors Gambaro, Stefania;La Manna, Pellegrino;De Rosa, Margherita;Soriente, Annunziata;Talotta, Carmen;Gaeta, Carmine;Neri, Placido;
Journal Frontiers in chemistry
Year 2019
DOI
10.3389/fchem.2019.00687
URL
https://www.frontiersin.org/article/10.3389/fchem.2019.00687/full
Keywords
self-assembly brønsted acid catalyst h-bond catalyst bis(heteroaryl)methanes resorcinarene hexameric capsule supramolecular organocatalysis

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