A simple and highly selective electrochemical label-free aptasensor of 17β-estradiol based on signal amplification of bi-functional graphene.

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ID: 76637
2019
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Abstract
In the present work, a convenient signal-on electrochemical label-free aptasensor for 17β-estradiol (E2), a typical steroidal hormones endocrine disrupting chemicals, was proposed. 6-mercapto-1-hexanol (MCH) self-assembled monolayer (SAM) modified Au (MCH/Au) electrode was used as the substrate electrode. Graphene is used with bi-functions, not only to adsorb E2 binding aptamer, serving as the recognition element to E2, but also to be assembled onto MCH/Au electrode when sensing E2, to controllably turn on the electron transfer (eT), and further indicate the signal to E2 concentration. With the synergistic effect of DNase I enzyme, highly sensitive detection of E2 was achieved at this aptasensing system, with a linear range from 0.07 to 10 pM and a detection limit of 50 fM. An outstanding selectivity towards E2 was proven for the sensing system by simultaneously detecting 100-fold potential co-existing interferences. The stability and reproducibility were also evaluated to be satisfactory. Spiked real water analysis further indicated its reliability and potential in practical environmental monitoring.
Reference Key
liu2019atalanta Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Liu, Meichuan;Ke, Hongyang;Sun, Caiqin;Wang, Guoqiang;Wang, Yu;Zhao, Guohua;
Journal Talanta
Year 2019
DOI
S0039-9140(18)31071-3
URL
Keywords
graphene 17β-estradiol electrochemical aptasensor signal cycling amplification

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