Increased midgestational IFN-γ, IL-4 and IL-5 in women bearing a child with autism: A case-control study

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ID: 75882
2011
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Abstract

Abstract

Background

Immune anomalies have been documented in individuals with autism spectrum disorders (ASDs) and their family members. It is unknown whether the maternal immune profile during pregnancy is associated with the risk of bearing a child with ASD or other neurodevelopmental disorders.

Methods

Using Luminex technology, levels of 17 cytokines and chemokines were measured in banked serum collected from women at 15 to 19 weeks of gestation who gave birth to a child ultimately diagnosed with (1) ASD (n = 84), (2) a developmental delay (DD) but not autism (n = 49) or (3) no known developmental disability (general population (GP); n = 159). ASD and DD risk associated with maternal cytokine and chemokine levels was estimated by using multivariable logistic regression analysis.

Results

Elevated concentrations of IFN-γ, IL-4 and IL-5 in midgestation maternal serum were significantly associated with a 50% increased risk of ASD, regardless of ASD onset type and the presence of intellectual disability. By contrast, elevated concentrations of IL-2, IL-4 and IL-6 were significantly associated with an increased risk of DD without autism.

Conclusion

The profile of elevated serum IFN-γ, IL-4 and IL-5 was more common in women who gave birth to a child subsequently diagnosed with ASD. An alternative profile of increased IL-2, IL-4 and IL-6 was more common for women who gave birth to a child subsequently diagnosed with DD without autism. Further investigation is needed to characterize the relationship between these divergent maternal immunological phenotypes and to evaluate their effect on neurodevelopment.

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Authors Goines Paula E, Croen Lisa A, Braunschweig Daniel, Yoshida Cathleen K, Grether Judith, Hansen Robin, Kharrazi Martin, Ashwood Paul, Van de Water Judy
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Journal Molecular autism
Year 2011
DOI
DOI not found
URL
http://www.molecularautism.com/content/2/1/13
Keywords
Medicine (General) Medicine Pediatrics otorhinolaryngology psychology neurosciences. biological psychiatry. neuropsychiatry neurology. diseases of the nervous system psychiatry philology. linguistics

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