Sustainability Challenges in Peptide Synthesis and Purification: From R&D to Production.

Clicks: 386
ID: 75419
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #16 of 103 articles by views in The Journal of organic chemistry

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
In recent years, there has been a growing interest in therapeutic peptides within the pharmaceutical industry with more than 50 peptide drugs on the market, approximately 170 in clinical trials, and >200 in preclinical development. However, the current state of the art in peptide synthesis involves primarily legacy technologies with use of large amounts of highly hazardous reagents and solvents and little focus on green chemistry and engineering. In 2016, the ACS Green Chemistry Institute Pharmaceutical Roundtable identified development of greener processes for peptide API as a critical unmet need, and as a result, a new Roundtable team formed to address this important area. The initial focus of this new team is to highlight best practices in peptide synthesis and encourage much needed innovations. In this Perspective, we aim to summarize the current challenges of peptide synthesis and purification in terms of sustainability, highlight possible solutions, and encourage synergies between academia, the pharmaceutical industry, and contract research organizations/contract manufacturing organizations.
Reference Key
isidrollobet2019sustainabilitythe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Isidro-Llobet, Albert;Kenworthy, Martin N;Mukherjee, Subha;Kopach, Michael E;Wegner, Katarzyna;Gallou, Fabrice;Smith, Austin G;Roschangar, Frank;
Journal The Journal of organic chemistry
Year 2019
DOI
10.1021/acs.joc.8b03001
URL
Keywords
environmental performance survey research structural equation modelling green supply chain management complementarity theory

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.