Use of GeneXpert and the role of an expert panel in improving clinical diagnosis of smear-negative tuberculosis cases.

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ID: 75164
2019
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Abstract
A high proportion of notified tuberculosis cases in the Philippines are clinically diagnosed (63%) as opposed to bacteriologically confirmed. Better understanding of this phenomenon is required to improve tuberculosis control.To determine the percentage of smear negative presumptive tuberculosis patients that would be diagnosed by GeneXpert; compare clinical characteristics of patients diagnosed as tuberculosis cases; and review the impact that the current single government physician and a reconstituted Tuberculosis Diagnostic committee (expert panel) may have on tuberculosis over-diagnosis.This a cross-sectional study of 152 patients 15-85 years old with two negative Direct Sputum Smear Microscopy results, with abnormal chest X-ray who underwent GeneXpert testing and review by an expert panel.Thirty-two percent (48/152) of the sample were Xpert positive and 93% (97/104) of GeneXpert negatives were clinically diagnosed by a single physician. Typical symptoms and X-ray findings were higher in bacteriologically confirmed tuberculosis. When compared to the GeneXpert results the Expert panel's sensitivity for active tuberculosis was high (97.5%, 39/40), specificity was low (40.2%, 35/87).Using the GeneXpert would increase the level of bacteriologically confirmed tuberculosis substantially among presumptive tuberculosis. An expert panel will greatly reduce over-diagnosis usually seen when a decision is made by a single physician.
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abong2019useplos Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Abong, Jovilia;Dalay, Victoria;Langley, Ivor;Tomeny, Ewan;Marcelo, Danaida;Mendoza, Victor;Aquino, Arvin Christian;Garfin, Anna Marie Celina;Squire, Bertie;Yu, Charles;
Journal PloS one
Year 2019
DOI
10.1371/journal.pone.0227093
URL
Keywords
Mycobacterium tuberculosis mdr-tb line probe assay smear-negative xpert mtb/rif assay

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