New Napyradiomycin Analogues from sp. Strain CA-271078.

Clicks: 407
ID: 74706
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #14 of 132 articles by views in Marine drugs

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 132 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
As part of our continuing efforts to discover new bioactive compounds from microbial sources, a reinvestigation of extracts of scaled-up cultures of the marine-derived sp. strain CA-271078 resulted in the isolation and structural elucidation of four new napyradiomycins (-, ). The known napyradiomycin SC (), whose structural details had not been previously described in detail, and another ten related known compounds (-). The structures of the new napyradiomycins were characterized by HRMS and 1D- and 2D-NMR spectroscopies and their relative configurations were established through a combination of molecular modelling with and coupling constants NMR analysis. The absolute configuration of each compound is also proposed based on biosynthetic arguments and the comparison of specific rotation data with those of related compounds. Among the new compounds, was determined to be the first non-halogenated member of napyradiomycin A series containing a functionalized prenyl side chain, while - harbor in their structures the characteristic chloro-cyclohexane ring of the napyradiomycin B series. Remarkably, compound displays an unprecedented 14-membered cyclic ether ring between the prenyl side chain and the chromophore, thus representing the first member of a new class of napyradiomycins that we have designated as napyradiomycin D1. Anti-infective and cytotoxic properties for all isolated compounds were evaluated against a set of pathogenic microorganisms and the HepG2 cell line, respectively. Among the new compounds, napyradiomycin D1 exhibited significant growth-inhibitory activity against methicillin-resistant , , and HepG2.
Reference Key
carreteromolina2019newmarine Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Carretero-Molina, Daniel;Ortiz-López, Francisco Javier;Martín, Jesús;Oves-Costales, Daniel;Díaz, Caridad;de la Cruz, Mercedes;Cautain, Bastien;Vicente, Francisca;Genilloud, Olga;Reyes, Fernando;
Journal Marine drugs
Year 2019
DOI
E22
URL
Keywords
Antimicrobial activity Cytotoxicity structural elucidation marine actinomycetes napyradiomycins

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.