Plakinamine P, A Steroidal Alkaloid with Bactericidal Activity against .

Clicks: 377
ID: 74704
2019
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Abstract
Tuberculosis is the leading cause of death due to infectious disease worldwide. There is an urgent need for more effective compounds against this pathogen to control the disease. Investigation of the anti-mycobacterial activity of a deep-water sponge of the genus revealed the presence of a new steroidal alkaloid of the plakinamine class, which we have given the common name plakinamine P. Its structure is most similar to plakinamine L, which also has an acyclic side chain. Careful dissection of the nuclear magnetic resonance data, collected in multiple solvents, suggests that the dimethyl amino group at the 3 position is in an equatorial rather than axial position unlike previously reported plakinamines. Plakinamine P was bactericidal against , and exhibited moderate activity against other mycobacterial pathogens, such as and . Furthermore, it had low toxicity against J774 macrophages, yielding a selectivity index (SI, or IC/MIC) of 8.4. In conclusion, this work provides a promising scaffold to the tuberculosis drug discovery pipeline. Future work to determine the molecular target of this compound may reveal a pathway essential for survival during infection.
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rodrigues-felix2019plakinaminemarine Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Rodrigues Felix, Carolina;Roberts, Jill C;Winder, Priscilla L;Gupta, Rashmi;Diaz, M Cristina;Pomponi, Shirley A;Wright, Amy E;Rohde, Kyle H;
Journal Marine drugs
Year 2019
DOI
E707
URL
Keywords
tuberculosis drug discovery marine compounds

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