Novel benzimidazole-acrylonitrile hybrids and their derivatives: Design, synthesis and antimycobacterial activity.

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ID: 74566
2019
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Abstract
This paper reports the synthesis and evaluation of some benzimidazole-acrylonitrile hybrid derivatives for their in vitro antimycobacterial activities against Mycobacterium tuberculosis H37Rv. Among the derivatives studied, 3b was found to be the most active compound with MIC of 0.78 μg/mL against M. tuberculosis. This is a quite good activity compared with ethambutol (MIC = 1.56 μg/mL). Moreover, 3b showed 2.8 log fold reduction in bacterial count of dormant forms of mycobacterium which is more potent than first line drugs isoniazid, ciprofloxacin, rifampicin and moxifloxacin. Having activities against both active and dormant forms of M. tuberculosis,3b may be a useful candidate for the development of new drugs to treat tuberculosis.
Reference Key
sirim2019noveleuropean Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sirim, Mustafa Mert;Krishna, Vagolu Siva;Sriram, Dharmarajan;Unsal Tan, Oya;
Journal European journal of medicinal chemistry
Year 2019
DOI
S0223-5234(19)31167-5
URL
Keywords
benzimidazole antimycobacterial activity acrylonitrile nutrient starvation test propanenitrile

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