Preimplantation Genetic Testing for Aneuploidy: A Review.

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ID: 74456
2019
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Abstract
Preimplantation genetic testing for aneuploidy (PGT-A) has undergone many technical developments over recent years, including changes in biopsy timings, methodology, and genetic analysis techniques. The evidence surrounding the efficaciousness of PGT-A is sporadic and inconsistent; as such, significant doubt and concern remain regarding its widespread implementation.This review seeks to describe the historical development of PGT-A and to analyze and summarize the current published literature.At times during its infancy, PGT-A failed to display conclusive improvements in results; with newer technologies, PGT-A appears to yield superior outcomes, including reductions in miscarriages and multiple gestations. Clinicians and patients should assess the use of PGT-A on a case-by-case basis, with laboratories encouraged to utilize blastocyst biopsy and next-generation sequencing when conducting PGT-A. Further studies providing cumulative live birth rates and time to live birth are required if PGT-A is to be proven as producing superior outcomes.PGT-A has the potential ability to impact in vitro fertilization success rates, and as it is increasingly adopted worldwide, it is crucial that clinicians are aware of the evidence for its continued use.
Reference Key
kemper2019preimplantationobstetrical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kemper, James M;Vollenhoven, Beverley J;Talmor, Alon J;
Journal obstetrical & gynecological survey
Year 2019
DOI
10.1097/OGX.0000000000000737
URL
Keywords
antimicrobial resistance mic neisseria gonorrhoeae amr ecoff gonococcus mic-shift

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