An apparatus based on an atomic force microscope for implementing tip-controlled local breakdown.

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ID: 74212
2019
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Abstract
Solid-state nanopores are powerful tools for sensing of single biomolecules in solution. Fabrication of solid-state nanopores is still challenging, however; in particular, new methods are needed to facilitate the integration of pores with larger nanofluidic and electronic device architectures. We have developed the tip-controlled local breakdown (TCLB) approach, in which an atomic force microscope (AFM) tip is brought into contact with a silicon nitride membrane that is placed onto an electrolyte reservoir. The application of a voltage bias at the AFM tip induces a dielectric breakdown that leads to the formation of a nanopore at the tip position. In this work, we report on the details of the apparatus used to fabricate nanopores using the TCLB method, and we demonstrate the formation of nanopores with smaller, more controlled diameters using a current limiting circuit that zeroes the voltage upon pore formation. Additionally, we demonstrate the capability of TCLB to fabricate pores aligned to embedded topographical features on the membranes.
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stdenis2019anthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors St-Denis, T;Yazda, K;Capaldi, X;Bustamante, J;Safari, M;Miyahara, Y;Zhang, Y;Grutter, P;Reisner, W;
Journal The Review of scientific instruments
Year 2019
DOI
10.1063/1.5129665
URL
Keywords
vitamin E drug delivery solid lipid nanoparticles (slns) solvent injection-homogenization technique α-tocopherol acetate

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