P-TSA catalyzed facile and efficient synthesis of polyhydroquinoline derivatives through hantzsch multi-component condensation.

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ID: 74080
2008
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Abstract
A facile and efficient synthetic route to polyhydroquinolines has been developed via four-component condensation reactions of aldehydes, dimedone, ethyl acetoacetate and ammonium acetate in the presence of p-toluenesulfonic acid (p-TSA) catalyst in ethanol at ambient temperature through Hantzsch reaction. Simple work-up procedure, environmentally friendly, inexpensive and non-toxic catalyst, shorter reaction times along with excellent product yields are the significant features of this practical method.
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cherkupally2008ptsachemical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Cherkupally, Sanjeeva Reddy;Mekala, Raghu;
Journal Chemical & pharmaceutical bulletin
Year 2008
DOI
DOI not found
URL URL not found
Keywords
Antimicrobial activity multicomponent reaction antimalarial activity 5-imidazopyrazole incorporated polyhydroquinolines antituberculosis activity

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