Enantioselective organocatalytic Hantzsch synthesis of polyhydroquinolines.

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ID: 74077
2009
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Abstract
The four-component Hantzsch reaction provides access to pharmaceutically important dihydropyridines. To expand the utility of this method, we have developed a route under organocatalytic conditions with good yields and excellent ee's. Through catalyst screening, we found that a BINOL-phosphoric acid allowed enantioselective synthesis of six-membered heterocycles with a variety of substitution patterns.
Reference Key
evans2009enantioselectiveorganic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Evans, Christopher G;Gestwicki, Jason E;
Journal Organic letters
Year 2009
DOI
10.1021/ol901114f
URL
Keywords
Antimicrobial activity multicomponent reaction antimalarial activity 5-imidazopyrazole incorporated polyhydroquinolines antituberculosis activity

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