Fiery Cell Death: Pyroptosis in the Central Nervous System.

Clicks: 395
ID: 73316
2019
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Ranked #5 of 21 articles by views in trends in neurosciences

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Abstract
Pyroptosis ('fiery death') is an inflammatory type of regulated cell death (RCD), which occurs downstream of inflammasome activation. Pyroptosis is mediated directly by the recently identified family of pore-forming proteins known as gasdermins, the best characterized of which is gasdermin D (GSDMD). Recent investigations implicate pyroptosis in the pathogenesis of multiple neurological diseases. In this review, we discuss molecular mechanisms that drive pyroptosis, evidence for pyroptosis within the CNS, and emerging therapeutic strategies for its inhibition in the context of neurological disease.
Reference Key
mckenzie2019fierytrends Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors McKenzie, Brienne A;Dixit, Vishva M;Power, Christopher;
Journal trends in neurosciences
Year 2019
DOI
S0166-2236(19)30218-8
URL
Keywords
central nervous system inflammasome pyroptosis neuron glia caspase regulated cell death

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